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TRIPLE GIP/GLP-1/GLUCAGON AGONIST

Retatrutide
Calculator

Calculate how many units to draw for your retatrutide dose. Pre-filled with clinical trial titration values and common vial sizes.

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Inputs
Peptide Amount (on label) = 10,000 mcg
mg
Bacteriostatic Water = 200 IU
mL
Desired Dose = 1.000 mg
mcg
Units to Draw
20.0 IU
Draw to the 20 mark on a standard insulin syringe
Concentration
50.0 mcg/IU
Doses per Vial
10 doses
Syringe Preview (100 IU)
0 10 20 30 40 50 60 70 80 100 20 IU
Retatrutide Dose Presets

Titration Schedule

The retatrutide titration schedule referenced from Phase 2 clinical trials starts low and increases every 4 weeks. This graduated approach allows the body to adjust at each level before moving to the next.

Weeks Weekly Dose mcg Units (10mg/2mL)
1 - 4 0.5 mg 500 mcg 10 IU
5 - 8 1 mg 1,000 mcg 20 IU
9 - 12 2 mg 2,000 mcg 40 IU
13 - 16 4 mg 4,000 mcg 80 IU
17 - 20 8 mg 8,000 mcg 160 IU
21+ 12 mg 12,000 mcg 240 IU

Common Vial Sizes

Retatrutide vials are available in several sizes. The number of doses per vial depends on your current titration level and how much bacteriostatic water you use for reconstitution.

5mg
10 doses at 0.5mg
10mg
20 doses at 0.5mg
15mg
30 doses at 0.5mg
30mg
60 doses at 0.5mg

Key Context

Weekly Dosing

Retatrutide has a half-life of approximately 5 days, which supports once-weekly subcutaneous administration. Many users choose a consistent day each week for dosing.

Triple Receptor Agonist

Retatrutide is a triple GIP/GLP-1/Glucagon receptor agonist currently in Phase 2/3 clinical trials. Its mechanism activates three receptor pathways involved in appetite signaling and energy metabolism.

Graduated Titration

Clinical trial protocols start at the lowest dose and increase every 4 weeks across six titration steps. This graduated approach is referenced in published Phase 2 dosing schedules.

Storage After Reconstitution

Reconstituted retatrutide is typically stored refrigerated at 2-8 degrees Celsius. Using bacteriostatic water (with benzyl alcohol) supports multi-use stability for 4-6 weeks.

Retatrutide Quick Reference

Half-life ~5 days
Frequency Once weekly
Route Subcutaneous
Dose range 0.5 - 12 mg/wk
Class GIP/GLP-1/Glucagon
Status Phase 2/3 Trials

Quick Notes

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1 mL = 100 units (IU) on a standard U-100 insulin syringe

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Always use bacteriostatic water (not sterile water) for multi-use vials

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Higher titration doses (8mg+) may require multiple syringe draws per dose

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Steady-state concentration is typically reached after 4-5 weekly doses at the same level

Frequently Asked Questions

The amount of bacteriostatic water depends on your desired concentration. Common reconstitution volumes are 1mL or 2mL. Adding 2mL to a 10mg vial gives a concentration of 50mcg per unit (IU), making it straightforward to measure doses on a standard insulin syringe. Less water means a more concentrated solution and fewer units to draw per dose.
It depends on your reconstitution. With a 10mg vial reconstituted in 2mL of bacteriostatic water, 1mg (1000mcg) equals 20 units (IU) on a standard insulin syringe. Use the calculator above to find the exact amount for your specific vial size and water volume.
The Phase 2 clinical trial titration schedule starts at 0.5mg per week for 4 weeks, then increases to 1mg for 4 weeks, 2mg for 4 weeks, 4mg for 4 weeks, 8mg for 4 weeks, and finally 12mg as the maximum trial dose. Each step allows blood concentration levels to stabilize before the next increase.
Retatrutide research vials are commonly available in 5mg, 10mg, 15mg, and 30mg sizes. The 10mg vial is widely used, providing enough compound for multiple weeks of dosing at lower titration steps. Larger vials are more cost-effective per milligram for users on higher maintenance doses.
Retatrutide is administered once per week via subcutaneous injection. Its half-life of approximately 5 days supports weekly dosing. Blood concentration levels build and stabilize over the first 4-5 weeks at each dose level, reaching steady state.
Reconstituted retatrutide is generally considered stable for 4-6 weeks when stored refrigerated at 2-8 degrees Celsius. Always use bacteriostatic water (not sterile water) for reconstitution, as the benzyl alcohol preservative helps maintain stability across multiple uses from the same vial.

Learn More

Retatrutide Profile

Half-life, dosing protocols, PK data, and FAQ.

How to Know It's Working

Week-by-week expectations on GLP-1 protocols.

Reconstitution Guide

Step-by-step mixing guide for beginners.
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