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GLP-1 AGONIST

Semaglutide
Calculator

Calculate how many units to draw for your semaglutide dose. Pre-filled with common titration values and vial sizes.

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Inputs
Peptide Amount (on label) = 5,000 mcg
mg
Bacteriostatic Water = 200 IU
mL
Desired Dose = 0.250 mg
mcg
Units to Draw
5.0 IU
Draw to the 5 mark on a standard insulin syringe
Concentration
25.0 mcg/IU
Doses per Vial
20 doses
Syringe Preview (100 IU)
0 10 20 30 40 50 60 70 80 100 5 IU
Semaglutide Dose Presets

Titration Schedule

A commonly referenced semaglutide titration schedule starts low and increases every 4 weeks. This graduated approach allows the body to adjust at each level before moving to the next.

Weeks Weekly Dose mcg Units (5mg/2mL)
1 - 4 0.25 mg 250 mcg 5 IU
5 - 8 0.5 mg 500 mcg 10 IU
9 - 12 1 mg 1,000 mcg 20 IU
13 - 16 1.7 mg 1,700 mcg 34 IU
17+ 2.4 mg 2,400 mcg 48 IU

Common Vial Sizes

Semaglutide vials are available in several sizes. The number of doses per vial depends on your current titration level and how much bacteriostatic water you use for reconstitution.

2mg
8 doses at 0.25mg
3mg
12 doses at 0.25mg
5mg
20 doses at 0.25mg
10mg
40 doses at 0.25mg

Key Context

Weekly Dosing

Semaglutide has a half-life of approximately 7 days, which supports once-weekly subcutaneous administration. Many users choose a consistent day each week for dosing.

GLP-1 Receptor Agonist

Semaglutide belongs to the GLP-1 receptor agonist class. Its mechanism involves activating GLP-1 receptors, which are involved in appetite signaling and glucose metabolism.

Graduated Titration

Common titration protocols start at the lowest dose and increase every 4 weeks. This graduated approach is widely referenced in published clinical dosing schedules.

Storage After Reconstitution

Reconstituted semaglutide is typically stored refrigerated at 2-8 degrees Celsius. Using bacteriostatic water (with benzyl alcohol) supports multi-use stability for 4-6 weeks.

Semaglutide Quick Reference

Half-life ~7 days
Frequency Once weekly
Route Subcutaneous
Dose range 0.25 - 2.4 mg/wk
Class GLP-1 Agonist

Quick Notes

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1 mL = 100 units (IU) on a standard U-100 insulin syringe

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Always use bacteriostatic water (not sterile water) for multi-use vials

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Steady-state concentration is typically reached after 4-5 weekly doses at the same level

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Many users administer on the same day each week for consistency

Frequently Asked Questions

The amount of bacteriostatic water depends on your desired concentration. Common reconstitution volumes are 1mL or 2mL. Adding 2mL to a 5mg vial gives a concentration of 25mcg per unit (IU), making it straightforward to measure doses on a standard insulin syringe. Less water means a more concentrated solution and fewer units to draw per dose.
It depends on your reconstitution. With a 5mg vial reconstituted in 2mL of bacteriostatic water, 0.25mg (250mcg) equals 5 units (IU) on a standard insulin syringe. Use the calculator above to find the exact amount for your specific vial size and water volume.
A commonly referenced titration schedule starts at 0.25mg per week for 4 weeks, then increases to 0.5mg for 4 weeks, 1mg for 4 weeks, 1.7mg for 4 weeks, and finally 2.4mg as the maintenance dose. Each step allows blood concentration levels to stabilize before the next increase.
Semaglutide research vials are commonly available in 2mg, 3mg, 5mg, and 10mg sizes. The 5mg vial is one of the most widely used, providing enough compound for multiple weeks of dosing at lower titration steps. Larger vials are more cost-effective per milligram for users on higher maintenance doses.
Semaglutide is typically administered once per week via subcutaneous injection. Its long half-life of approximately 7 days supports weekly dosing. Blood concentration levels build and stabilize over the first 4-5 weeks at each dose level, reaching steady state.
Reconstituted semaglutide is generally considered stable for 4-6 weeks when stored refrigerated at 2-8 degrees Celsius. Always use bacteriostatic water (not sterile water) for reconstitution, as the benzyl alcohol preservative helps maintain stability across multiple uses from the same vial.

Learn More

Semaglutide Profile

Half-life, dosing protocols, PK data, and FAQ.

Understanding Steady State

How semaglutide builds to peak over 5 weeks.

Reconstitution Guide

Step-by-step mixing guide for beginners.
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Track your semaglutide protocol

Dose scheduling, real-time concentration curves, titration tracking, and weekly reminders. See exactly where your levels are.

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