Mitochondrial-derived peptide (16 amino acids). Half-life approximately 2 hours, but downstream signaling effects persist well beyond plasma clearance. Early-stage research.
MOTS-c is classified as a healing peptide in Milligram's compound library. Mitochondrial-derived peptide (16 amino acids).
With a half-life of ~2 hours, MOTS-c requires daily administration in most observed protocols. Administered via SubQ injection, it has a bioavailability of approximately 95% via its primary route.
Half-life approximately 2 hours, but downstream signaling effects persist well beyond plasma clearance. Early-stage research. Subcutaneous administration. One-compartment model.
MOTS-c's pharmacological activity involves the following key pathways:
MOTS-c interacts with cellular repair pathways. Its mechanism involves modulation of growth factors and signaling cascades relevant to tissue recovery.
After subcutaneous administration, MOTS-c enters systemic circulation and distributes to target tissues where it exerts its pharmacological effects.
| Parameter | Value |
|---|---|
| Half-Life | ~2 hours |
| Bioavailability | ~95% |
| Time to Peak | ~30 minutes |
| Duration of Activity | ~7 days |
| Routes | Subcutaneous |
The following protocols represent commonly observed dosing patterns. These are observational summaries, not recommendations.
MOTS-c is supplied as a lyophilized (freeze-dried) powder and requires reconstitution before use. Common vial sizes: 5 mg, 10 mg.
You will need your MOTS-c vial (lyophilized powder), a vial of bacteriostatic water, two syringes (one for transferring water, one for injecting), alcohol swabs, and a clean flat surface.
Wipe the rubber stopper on both the MOTS-c vial and the bacteriostatic water vial thoroughly with separate alcohol swabs. Allow them to air dry for 30 seconds before proceeding.
Using a clean syringe, draw the desired volume of bacteriostatic water (typically 1–2 mL). For a 5 mg vial reconstituted with 1 mL of BAC water, each 0.1 mL drawn will equal 0.5 mg of MOTS-c.
Insert the syringe needle into the MOTS-c vial at an angle and slowly push the bacteriostatic water down the inner glass wall — never directly onto the powder. This prevents denaturation of the peptide. Do not shake the vial.
Gently roll the vial between your palms in a circular motion until the powder is fully dissolved and the solution runs clear. This typically takes 30–60 seconds. Do not shake or vortex the vial.
Once reconstituted, store the vial in the refrigerator at 2–8°C protected from light. Label the vial with the date of reconstitution. Reconstituted MOTS-c is typically stable for 4–6 weeks when refrigerated.
5 mg vial + 1 mL BAC water = 5 mg/mL. A 5 mg weekly dose = draw 0.1 mL (10 units on a U100 insulin syringe) per injection if taken as a single weekly dose. Use the Milligram reconstitution calculator for custom vial sizes.
Lyophilized MOTS-c is stable at room temperature for several months. Once reconstituted, refrigerate at 2–8°C and use within 4–6 weeks. Avoid repeated freeze-thaw cycles and direct light exposure.